I have never heard anyone state that MRDS on pistols will reduce "mistake of fact" shootings. That is a new one on me. The standard argument is that MRDS usage will increase hits on the bad guy. Never mind, a shooter snatching a trigger on a MRDS pistol will miss just as bad as he would with iron sights.
IMO, red dots provide a much quicker firing solution over iron sights. Also, as I’ve gotten older and more dependent on readers, I have trouble picking up the irons. I plan to red dot as many of my guns as possible.